Dernières parutions concernant le CECS

Désolée, les articles sont en anglais et je n'ai pas le temps de les traduire.

Premier article du Dr.Juliane von Kurnatowski de l'Université Vétérinaire de Hannovre. Cet article est extrait de la thèse de doctorat présentée par cette jeune vétérinaire, je peux communiquer le texte complet de la thèse (en allemand - 130 pages) qui ne porte que sur le CECS

Within the framework of her dissertation Juliane von Kurnatowski of the Clinic for small companion animals of the Stiftung Tierärztliche Hochschule Hannover investigated the clinical and genetic aspects of cramping episodes in Border Terriers.

Because of the frequent occurrence of cramping episodes in certain subpopulations of this dog breed and the repeated occurrence of them in some families, a genetic background was assumed. By means of a questionnaire distributed among Border Terrier owners 267 forms with information on 365 dogs could be analysed. In the first place the prevalence (=the number of cases in the population at a given moment in time) of cramping episodes in Border Terriers in Germany was estimated and at the same time an evaluation of the nature of the cramping episodes was carried out.

Through pedigree examination and segregation analysis (= assessment through statistic calculations of the most likely mode of inheritance in the families used in the project) the mode of inheritance could in the end be determined. In 70% of the affected Border Terriers (47 in all) cramping episodes occurred which affected the whole body, 45% of which became suddenly rigid in a characteristic way.

Just like BorderTerriers Dachshunds, Poodles and other terrier breeds may suffer from episodes which cause the whole body to become rigid. On the other hand cramping episodes occur in dog breeds like Golden and Labrador Retrievers, Bernese and Irish Wolfdogs that also affect the whole body, but during which the dogs often lose consciousness. Stages of stiffening alternate with paddling movements.

The Border Terriers participating in this research were on average 3,73 years old and had their first cramping episode at an average of 3,13 years.

Very extensive diagnostics yielded no deviations from the norm. Through supplementary laboratory research (metabolic screening = determining the levels of amino acids, organic acids, purins, pyrimidins in urine and blood serum) the existence of a congenital metabolic defect could be ruled out. It is assumed that in this breed we are dealing with an idiopathic (=without identifiable cause) form of epilepsy.

The average Inbreeding Coefficient (COI) of the Border Terriers was 3,85%, with the affected litters showing a not-significant higher COI than the non-affected litters.

Because of the very high prevalence of 13,1% and a high heritability of 0,51 the presence of a genetic effect should be considered very likely.

Furthermore it was proven that gender (males) and age (young dogs) have a significant influence on the occurrence of the condition. 10 linked pedigrees of at least 5 generations which produced 31 of the 47 affected Border Terriers were drawn up. From the pedigree analysis it became clear that the majority of the affected dogs were produced by healthy parents. The combinations of either two healthy parents or a healthy and an affected parent produced litters consisting of healthy and affected progeny. The repeated occurrence of affected dogs in different litters from the combination of the same sire but with different dams or the combination of the same dams with different sires strengthens the suspicion that we are dealing with a genetic component.

In view of the suspicion of a genetic component segregation analysis was executed to establish the mode of inheritance. This resulted in the belief that the mode of inheritance in the case of the cramping episodes in the Border Terrier is autosomal-recessive.

In view of the established genetic background and the autosomal-recessive mode of inheritance affected aniumals and their first grade relatives (full siblings, parents) should not be used for breeding.

Furthermore a combination which has produced affected progeny should not be repeated.

The identification of the genes responsible for the cramping episodes would be of great help to prevent more effectively the occurrence of the disease and to identify carriers of the condition in time.

Second article du Dr.Quirine Stassen de l'Université Vétérinaire d'Utrecht hollande, sui fait un point sur l'avancée des recherches qui y sont menées depuis plusieurs années.

As you may know already the University of Utrecht Clinic for Companion Animals (UKG) are researching the cramping episodes in Border Terriers.

This condition is characterized, among others, by episodic occurrence of cramping of the legs, neck and/or back, during which many dogs remain conscious. As the episodes occur more often in certain families it is assumed that we are dealing with a genetic condition.

Elaborate clinical examinations(physical, urine, very extensive blood panels looking for all possible causes for cramping episodes known in human and veterinary medicine and MRI-scans of the brain) did not result in finding the cause behind it.

Target of the research at UKG is to describe the condition, find the underlying genetic foundation and in the end (hopefully!!) develop a diagnostic DNA test.

By means of a DNA-test we will be able to distinguish between carriers (dogs without symptoms but carrying the genetic change) and genetically healthy animals. On this basis breeders can get advice on the use of certain combinations so as to prevent sufferers from being born. This does not mean that carriers, who possibly have other valuble genetic qualities, have to be excludud from breeding.

Thanks to the cooperation of hundreds of owners and the NBTC (Nederlandse Border Terrier Club) we have been able to collect more than 250 blood samples of Border Terriers suffering from cramping episodes ('sufferers'), their healthy relatives and healthy unrelated dogs! In addition we received more than 150 filled out questiuonnaires.

Meanwhile a genomescan (genome = one complete set of chromosomes) was performed, during which the DNA (genetic material) of sufferers was compared to that of healthy animals.

The major part of the genetic material of all dogs is identical, but in some parts so called SNIPs can be found. A SNIP (Single Nucleotide Polymorphism) is a variation in the DNA of only one nucleotide. In every animal we can find many SNIPs, spread all over the genetic material. Most of the time it doesn't matter for the functionality of the dog which nucleotide he has got on the locatiuon of a SNIP.

If a mutation (change in the genetic material) takes place and is passed on to the progeny, the SNIPs that lie close to it will be passed on linked to this mutation. When looking for an unknown (pathogenic) mutation known SNIPs can be used to locate that mutation.

With the genomescan nearly 16.000 known SNIPs, spread out over the DNA, were defined in each blood sample. Subsequently an examination took place to see whether there might be a connection between suffering from cramping episodes and the occurrence of certain nucleotides in these SNIPs.

It may be clear that the determination of about 16.000 SNIPs will yield an enormous amount of information. For many weeks a computer was busy carrying out all the statistic calculations. During the procedure some suspect areas were found on the DNA, but, alas, no real peaks.

A possible reason for this might be that the cramping episodes are not caused by only one, but more mutations. Dit makes the search for the genetic background a lot more complex.

Besides the occurrence of the episodes may not depend on genetic factors only, but also on environmental factors.

Another problem might be the fact that our information is not always up to date. It may happen that a Border Terrier was completely healthy at the time of taking the blood sample, but that later on in life cramping episodes did occur. Therefore we will get into contact with several owners of dogs who submitted blood samples to ask if our data are still relevant.

In the near future we are going to examine the found suspect areas one by one. This will be an enormous task, but if we have new results to report, we will, of course, keep you posted.

We would like to express our gratitude once again to all Border Terrier owners who have donated their dogs' blood samples, filled out the questionnaire or assisted in any other way !

On behalf of the research team,

Désolée pour ce long post, mais ces recherches sontdes plus intéresantes et nous concernent tous.
Si j'ai du emps j'en ferai une traduction.
Bonne lecture

ho oui merci Brigitte ...parce que là alors...avec ma bosse et mon mal de crâne ...je tente même pas !

je ne sais pas lire au secours en français STP
merci Brigitte

isabelle a écrit:

ho oui merci Brigitte ...parce que là alors...avec ma bosse et mon mal de crâne ...je tente même pas !

et sans lunettes

Merci Brigitte
C'est très interessant !

Carole

CAROLE a écrit:

Merci Brigitte
C'est très interessant !

Carole

Carole explique aux ignardes

CAROLE a écrit:

Merci Brigitte
C'est très interessant !

Carole

Prétentieuse !

Promis quand j'ai du temps je me colle à la traduction.....

@ Joëlle : c'est un état d'avancement des recherches sur le CECS

@ Isabelle : yes Ma'am

Carole

C'est sur Joelle la Carole elle nous prend pour de vraies billes !

isabelle a écrit:

C'est sur Joelle la Carole elle nous prend pour de vraies billes !

Elle ne doit pas connaitre ce proverbe
La culture c'est comme la confiture moins on en a plus on étale

ha ben oui tiens Carole prends ça et toc !

Isa je crois qu'on pollue le post on va se faire enguirlander.

c'est fini on arrête !
y a t'il un modérateur dynamique pour faire disparaitre nos idioties ?

profitez en les filles, je suis de bonne humeur aujourd'hui, c'est bientôt alors ce ne sera pas mais seulement

euh ? le bisous édenté... pas pour moi, merci

Carole

allez Isa on peut se lacher nous avons l'autorisation.

ouais !!! se défouler raconter des idioties qui ne concerne pas le sujet nananère c'est la Mini avec ses pantoufles rouges qui va être contente en rentrant !

C'est Noel

et vlan les modos

ouis mais on fera du ménage aant que Mini revienne

Très intéressant en effet ! Est ce qu'il ya des possibilités d'avoir les pedigrees des chiens atteints quelque part pour avoir une idée des lignées à risque et éviter ainsi de faire de la consanguinité dessus ???

je te l' envoie par mail (gros document), et c'est une liste évolutive qui est remise à jours environ tous les 3 mois.
La liste que je t'adresse est la Open List, mais il existe aussi une Closed List sur laquelle figure des chiens pour lequels les propriétaires n'ont pas décidé de rendre public le problème, mais en ont tout de même informé les gens qui travail sur le sujet.
Et puis il y a tous les chiens dont les propriétaires ou éleveurs ne veulent rien savoir et il y en a malheuresement beaucoup.
Ce sont les propriétaires et éleveurs qui communiquent les noms et pedigrees des chiens atteints et donnent l'aurtorisation de les faire figurer sur les liste.

Merci Brigitte. Nous avons aussi un listing international pour les épagneuls du tibet concernant une tare oculaire : PRA mais c'est clair qu'en France très peu d'éleveurs font un dépistage régulier donc pas de problème de PRA en France alors qu'il en existe dans les autres pays !!!

est-ce que quelqu'un pourrait m'expliquer ce qu'est le CCES svp? merci